Miss Alexis Barr

Interests

The centrosome is the major microtubule organising centre in the cell. Centrosomal abnormalities are common in epithelial cancers, including aberrations in both structure and number. As the largest protein complex in the cell, the centrosome is also an important signalling platform. We are interested in centrosome biology, in particular in the function of this organelle in mitosis, genome stability and polarity.

Research Focus

Keywords

Centrosome

Mitosis

Cancer sites

brain and central nervous system

breast

cervix

colorectal

uterus and unspecified

Equipment

Cell culture

Confocal microscopy

DNA sequencing

Fluorescence microscopy

Genomics

Imaging

Microscopy

PCR

Protein biochemistry

Protein purification

Recombinant protein expression

RNAi