Professor Carlos Caldas
Professor Carlos Caldas is pleased to consider applications from prospective PhD students.
Research on specific cancer types
BREAST CANCER FUNCTIONAL GENOMICS
The molecular taxonomy of breast cancers has revealed a complexity that suggests that different cancers have different cells of origin. The identification and characterisation of these cancer stem cells and their disrupted pathways is one of our research priorities. In parallel we will continue to prospectively validate prognostic and predictive signatures and therapeutic targets with the aim of clinical application.
Naderi A, Teschendorff AE, Beigel J, Cariati M, Ellis IO, Brenton JD, and Caldas C (2007). Bex2 is overexpressed in a subset of primary breast cancers and mediates NGF/NF-kB inhibition of apoptosis in breast cancer cell lines. Cancer Research 67: 6725–6736
Teschendorff AE, Journée M, Absil P-A, Sepulchre R, and Caldas C (2007). Elucidating the altered transcriptional programs in breast cancer using Independent Component Analysis. PLoS Computational Biology, 3(8):e16
Chin S-F, Wang Y, Thorne NP, Teschendorff AE, Pinder SE, Vias M, Naderi A, Roberts I, Barbosa-Morais NL, Garcia MJ, Iyer NG, Kranjac T, Robertson JFR, Aparicio S, Tavaré S, Ellis IO, Brenton JD, and Caldas C (2007), “Using array-comparative genomic hybridization to define molecular portraits of primary breast cancers”, Oncogene 26:1959–1970