Professor David Neal

University position

Professor

Professor David Neal is pleased to consider applications from prospective PhD students.

Departments

Department of Oncology and Department of Surgery

Institutes

Cancer Research UK, Cambridge Research Institute

Home page

http://science.cancerresearch...

Research Themes

Cancer biology and in vivo models

Clinical trials

Interests

The ProtecT Trialists (the largest ever randomised trial of surgery in early prostate cancer)
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Principal Investigator on large clinical trial of surgery, radiotherapy and monitoring in early prostate cancer (NHS R&D funded - £36M). Lead investigator on ProMPT (translational research programme in prostate cancer funded by NCRI [£2M]). Both are leading to generation of large bio-repositories. Group Leader in CRI with interest in androgen resistant prostate cancer studying neuroendocrine differentiation and novel transcription factors, use of ChIP on ChIp to detect novel binding sites for the androgen receptor, and the study of putative biomarkers including HiP1 and LYRIC in prostate cancer.

Research Focus

Key publications

DONOVAN J, MILLS N, SMITH M, BRINDLE L, JACOBY A, PETERS T, FRANKEL S, NEAL D, HAMDY F, (2002) Quality improvement report—Improving design and conduct of randomised trials by embedding them in qualitative research: ProtecT (prostate testing for cancer and treatment) study. British Medical Journal, 325, 766–769.

GAUGHAN L, LOGAN IR, NEAL DE, ROBSON CN, (2005) Regulation of androgen receptor and histone deacetylase 1 by Mdm2-mediated ubiquitylation. Nucleic Acids Research, 33, 13–26.

MILLS IG, GAUGHAN L, ROBSON C, ROSS T, MCCRACKEN S, KELLY J, NEAL DE (2005), “Huntingtin interacting protein 1 modulates the transcriptional activity of nuclear hormone receptors”, Journal of Cell Biology 170:191–200