Dr Duncan Odom
Our goal is to understand the systems-level transcriptional mechanisms underlying mammalian cell specification, which are often perturbed in carcinoma. We use liver hepatocyte as model cell types.
D. Schmidt PC, Scwalie, et al. “Waves of repeat-driven CTCF binding expansions have shaped mammalian genomes,” Cell 148 (2012) 1, C, Kutter G, Brown A, et al. “Pol III binding in six mammalian genomes shows high conservation among amino acid isotypes, despite divergence in tRNA gene usage.” Nature Genetics 43 (2011) 948.
D, Schmidt MD, Wilson B, Ballester, et al. “Five vertebrate ChIP-seq reveals the evolutionary dynamics of transcription factor binding,” Science 327 (2010) 1036.
D, Schmidt PC, Scwalie, et al. “A CTCF-independent role for cohesin in tissue-specific transcription,” Genome Research 20 (2010) 578.
MD, Wilson NL, Barbosa-Morais, et al. “Species-specific transcription in mice carrying human chromosome 21,” Science 322 (2008) 434.
Elizabeth Fisher Web: http://www.cnmd.ac.uk/researc...
Victor Tybulewicz Web: http://www.nimr.mrc.ac.uk/imm...
Benjamin Blencowe Web: http://www.utoronto.ca/intron/