Dr Duncan Odom

Duncan Odom

University position

Principal Investigator

Institutes

Cancer Research UK, Cambridge Research Institute and Wellcome Trust Sanger Institute

Home page

http://www.sanger.ac.uk/resea...

Research Themes

Systems biology

Cancer genomics

Interests

Our goal is to understand the systems-level transcriptional mechanisms underlying mammalian cell specification, which are often perturbed in carcinoma. We use liver hepatocyte as model cell types.

Research Focus

Keywords

genomics

transcriptional regulation

sequencing

hepatocytes

gene expression

Cancer sites

liver

Equipment

Bioinformatics

DNA sequencing

Gene expression profiling

Genomics

Microarray

Model organisms

PCR

Proteomics

RNAi

Statistical analysis

Key publications

D. Schmidt PC, Scwalie, et al. “Waves of repeat-driven CTCF binding expansions have shaped mammalian genomes,” Cell 148 (2012) 1, C, Kutter G, Brown A, et al. “Pol III binding in six mammalian genomes shows high conservation among amino acid isotypes, despite divergence in tRNA gene usage.” Nature Genetics 43 (2011) 948.

D, Schmidt MD, Wilson B, Ballester, et al. “Five vertebrate ChIP-seq reveals the evolutionary dynamics of transcription factor binding,” Science 327 (2010) 1036.

D, Schmidt PC, Scwalie, et al. “A CTCF-independent role for cohesin in tissue-specific transcription,” Genome Research 20 (2010) 578.

MD, Wilson NL, Barbosa-Morais, et al. “Species-specific transcription in mice carrying human chromosome 21,” Science 322 (2008) 434.

Collaborators

Cambridge

David Adams

Alvis Brazma

Paul Flicek

John Marioni

United Kingdom

Elizabeth Fisher Web: http://www.cnmd.ac.uk/researc...

Victor Tybulewicz Web: http://www.nimr.mrc.ac.uk/imm...

International

Benjamin Blencowe Web: http://www.utoronto.ca/intron/