Dr David Sargan

David Sargan

University position

Senior Lecturer

Dr David Sargan is pleased to consider applications from prospective PhD students.

Departments

Department of Veterinary Medicine

Email

drs20@cam.ac.uk

Home page

http://www.vet.cam.ac.uk/rese... (personal home page)

Research Themes

Cancer genomics

Basic biology (model organisms)

Interests

The short chromosomes of the dog are most easily analysed using chromsome painting. Here two translocation chromosome are shown in a fibrosarcoma.
The short chromosomes of the dog are most easily analysed using chromsome painting. Here two translocation chromosome are shown in a fibrosarcoma.
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My lab is using genomic mapping techniques to identify genes associated with breed specific predispositions to particular cancers in dogs. Current projects are histiocytic sarcoma in flat coated retrievers, splenic haemangisosarcoma in German shepherd dogs and adenocarcinoma in cocker spaniels. We are also applying cytogenetic analyses to the same tumours.

Research Focus

Keywords

dog

comparative

predisposition

Cancer sites

bone and connective tissue

spleen

Equipment

Bioinformatics

DNA sequencing

Genomics

Microarray

Microscopy

Key publications

Sargan DR, Aguirre-Hernandez J, Galibert F and Ostrander EO. (2007) An extended microsatellite set for linkage mapping in the domestic dog. J Heredity 98:221–31

Sargan DR, Milne BS, Aguirre Hernandez J, O’Brien PCM, Malcolm A Ferguson-Smith MA, Tess Hoather T and Dobson JM (2005), “Chromosome rearrangements in canine fibrosarcomas”, J Heredity 96:766–773

Milne BS, Hoather T, O’Brien PCM, Yang F, Ferguson-Smith MA, Dobson J, Sargan DR (2004), “Karyotype of canine soft tissue sarcomas: a multi-colour, multi-species approach to canine chromosome painting”, Chromosome Res 12:825–835

Collaborators

No collaborators listed