Dr John Stingl

John Stingl

University position

Junior Group Leader

Institutes

Cancer Research UK, Cambridge Research Institute

Email

john.stingl@cancer.org.uk

Home page

http://www.cambridgecancerres... (personal home page)

Research Themes

Cancer biology and in vivo models

Research on specific cancer types

Interests

Whole mount image of a mammary gland reconsituted with a mammary stem cell
Whole mount image of a mammary gland reconsituted with a mammary stem cell
View image full-size

My research focuses on identifying stem and progenitor cells in both the human and mouse mammary glands. I am interested in these cells because cancer theory suggests that it is these cells that are the initial targets for malignant transformation. I am also interested in understanding the influence of common breast cancer-associated mutations on normal breast stem and progenitor cell function and identifying the cell of origin of different types of breast tumours.

Research Focus

Keywords

breast

cancer

stem

Cancer sites

breast

Equipment

Cell culture

Flow cytometry

Immunohistochemistry

In vivo modelling

Key publications

Eirew P, Stingl J, Raouf A, Turashvili G, Aparicio S, Emerman J.T and Eaves CJ, (2008) A method for quantifying normal human mammary epithelial stem cells with in vivo regenerative ability. Nature Medicine (in press).

Stingl J, and Caldas C (2007), “Molecular heterogeneity of breast carcinomas and the cancer stem cell hypothesis”, Nature Reviews Cancer 7: 791 9:

Stingl J, Eirew P, Ricketson I, Shackleton M, Vaillant F, Choi D, Li HI, and Eaves CJ (2006), “Purification and unique properties of mammary epithelial stem cells”, Nature 439: 993 7:

Collaborators

Cambridge

Caldas Carlos

Christine Watson