Dr John Stingl
Junior Group Leader
http://www.cambridgecancerres... (personal home page)
Cancer biology and in vivo models
Research on specific cancer types
My research focuses on identifying stem and progenitor cells in both the human and mouse mammary glands. I am interested in these cells because cancer theory suggests that it is these cells that are the initial targets for malignant transformation. I am also interested in understanding the influence of common breast cancer-associated mutations on normal breast stem and progenitor cell function and identifying the cell of origin of different types of breast tumours.
Eirew P, Stingl J, Raouf A, Turashvili G, Aparicio S, Emerman J.T and Eaves CJ, (2008) A method for quantifying normal human mammary epithelial stem cells with in vivo regenerative ability. Nature Medicine (in press).
Stingl J, and Caldas C (2007), “Molecular heterogeneity of breast carcinomas and the cancer stem cell hypothesis”, Nature Reviews Cancer 7: 791 9:
Stingl J, Eirew P, Ricketson I, Shackleton M, Vaillant F, Choi D, Li HI, and Eaves CJ (2006), “Purification and unique properties of mammary epithelial stem cells”, Nature 439: 993 7: