Professor Paul Pharoah

Paul Pharoah

University position

Professor

Professor Paul Pharoah is pleased to consider applications from prospective PhD students.

Departments

Department of Oncology and Department of Public Health and Primary Care

Institutes

Strangeways Research Laboratory

Email

paul1@srl.cam.ac.uk

Home page

http://www.srl.cam.ac.uk/

Research Themes

Epidemiology

Data analysis and modelling

Interests

Chromosomal location of common susceptibility alleles for breast, ovarian and prostate cancer
Chromosomal location of common susceptibility alleles for breast, ovarian and prostate cancer
View image full-size

I am interested in the architecture of genetic susceptibility to common cancers (primarily breast, ovarian and colorectal). I am also interested in understanding how germline genetic variation influences disease heterogeneity and heterogeneity in the clinical outcomes of cancer.

Research Focus

Keywords

genetic epidemiology

risk prediction

pathology

prognosis

Cancer sites

breast

colorectal

No direct clinical relevance

ovary

Equipment

Bioinformatics

DNA sequencing

Epidemiology

Immunohistochemistry

Public health

Key publications

1. Bolton KL, Chenevix-Trench G, Goh C, Sadetzki S, Ramus SJ, Karlan BY, et al. Association between BRCA1 and BRCA2 mutations and survival in women with invasive epithelial ovarian cancer. JAMA 2012;307(4):382–90.

2, Pharoah PD, Antoniou AC, Easton DF, Ponder BA. Polygenes, risk prediction, and targeted prevention of breast cancer. N Engl J Med 2008;358(26):2796–803.

3, Pharoah PD, Tsai YY, Ramus SJ, Phelan CM, Goode EL, Lawrenson K, et al. GWAS meta-analysis and replication identifies three new susceptibility loci for ovarian cancer. Nat Genet 2013;45(4):362–70.

Collaborators

Cambridge

James Brenton

Carlos Caldas

Douglas Easton

Rebecca Fitzgerald

Bruce Ponder

International

Andrew Berchuck

Georgia Chenevix-Trench

Simon Gayther

Per Hall

Leigh Pearce